Methylnaltrexone (Relistor) for opioid induced constipation.
نویسنده
چکیده
www.aafp.org/afp Volume 82, Number 6 ◆ September 15, 2010 Methylnaltrexone (Relistor) is labeled for the treatment of opioid-induced constipation in patients with advanced illness who have not responded to laxative therapies.1 As a selective antagonist of peripheral mu-opioid receptors, methylnaltrexone inhibits opioidinduced gastrointestinal (GI) hypomotility without central nervous system effects such as sedation or change in mental status.2 Methylnaltrexone (Relistor) for Opioid-Induced Constipation
منابع مشابه
Utilization of methylnaltrexone (relistor) for opioid-induced constipation in an oncology hospital.
age insert states that methylnaltrexone “is indicated for the treatment of opioid-induced constipation in patients with advanced illness who are receiving palliative care, when response to laxative therapy has not been sufficient.”8 These details were included as a consequence of the clinical trials, which had been conducted in patients receiving opioid therapy, consisting of a median daily bas...
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Constipation is a common symptom in palliative care patients which can generate considerable suffering. There is uncertainty about the choice of treatment options from varying recommendations for management of constipation and a varying clinical practice in palliative care settings. The purpose of the review was to evaluate the current recommendations of therapy guidelines for the management of...
متن کاملMethylnaltrexone: the evidence for its use in the management of opioid-induced constipation
INTRODUCTION Constipation is a distressing side effect of opioid treatment, being so irksome in some cases that patients would rather suffer the pain than the side effect of opioid analgesics. Stool softeners or stimulating laxatives are often ineffective or even aggravate the situation. A new efficacious and safe drug is needed to limit the frequently observed side effects induced by effective...
متن کاملClinical Medicine Insights: Therapeutics
Objectives: Review and summarize the mechanism of action of methylnaltrexone bromide (methylnaltrexone) and its effectiveness in the treatment of opioid-induced constipation. Data Source: A multi-database search was conducted using PubMed and MEDLINE databases, in addition to electronic links to related articles and references. Background: Opioids are effective medications for the management of...
متن کاملMethylnaltrexone in the treatment of opioid-induced constipation
Opioids are the drugs of choice for treating moderate-to-severe pain, especially for patients in the end stage of cancer or other advanced illnesses, and also in critical care or for the treatment of chronic pain. Side effects such as nausea, pruritus, dizziness and constipation have to be controlled in order to use these drugs to their full potential. Opioid-induced bowel syndrome and constipa...
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ورودعنوان ژورنال:
- The Medical letter on drugs and therapeutics
دوره 50 1292 شماره
صفحات -
تاریخ انتشار 2008